Program At a Glance
Preliminary Program
| 18:30-19:00 | OPENING CERIMONY |
| 19:00-19:50 | Opening Session - Keynote Conference 1: Luke O’Neill (TCD / Ireland) Krebs Cycle reborn in macrophage activation Chair: Pedro Moraes-Vieira (UNICAMP / SP) |
| 20:00-22:00 | OPENING COCKTAIL |
| Room 1 | Room 2 | Room 3 | |
| 8:00 - 8:50 | BD BIOSCIENCE course Spectral and conventional flow cytometry: discover the main differences and the flexibility to choose between them in a single equipment. | ||
| Morning | Room 1 | Room 2 | Room 3 |
| SYMPOSIUM 1: Immuneregulation Chair: Ana Paula Lepique (USP / SP) | SYMPOSIUM 2: Adipose Tissue and obesity Chair: Tatiani Uceli Maioli (MG) | SYMPOSIUM 3: Cell Host & Microbe Chair: Walderez Dutra |
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| 9:00 - 9:30 | Restoring the immune response for cancer and HIV cures Rafick Sekaly (Emory / USA) | Perivascular Macrophages in the intersection of tissue health and disease pathophysiology Hernandez Moura Silva (MIT / USA) | Exploring metabolic reprogramming in Leishmania sp infection Claudia Brodsky (FioCruz / RJ) |
| 9.30 - 10:00 | Dissecting the Tumor Microenvironment in Kidney Cancer Kimryn Rathmell (VUMC / USA) | Regulation of the aging adipose-resident immune compartment Emily Goldberg (UCSF / USA) | The Immunometabolic Impact of SARS-CoV-2 on the Syrian Hamster Brain. Jean Pierre (USP / SP) |
| 10:00 - 10:15 | 1765 - Leptin Favors Imbalance of Antigen-specific CD4+ T Cells Associated with Seveity of Cat Allergy Hugo Akirito de Almeida Oyamada | 2131 - Microglia Derived Extracellular Mitochondria Modulate Neuronal Survival and Function Monara Kaelle Servulo Cruz Angelim | 1894 - HIF2α Signaling Pathway in Myeloid Leukocytes Promotes Susceptibility To Iinfection With Mycobacterium Tuberculosis Joseana de Oliveira |
| 10.15 - 10:30 | 1839 - NAIP/NLRC4 inflammasome activation by Trypanosoma cruzi relies on cathepsins Marcelo Pires Amaral | 1951 - CD4+ T Cells of Children and Adolescents With Obesity Present an Altered Pattern Of Expression of Cytokines, Transcription Factors, and Costimulatory Molecules Rafael Silva Lima | 1933 - Lipid Accumulation Modulates Dendritic Cell Activation, Inflammatory Response and Bacterial Burden During M. bovis BCG Infection Guilherme Iack Pinheiro da Cruz |
| 10:30 - 10:45 | 1830 - Sting Expressed in Nociceptors Regulates the Development of Cisplatin-Induced Neuropathic Pain Fabio Bonifacio de Andrade | 2184 - Obesity alters the macrophages response to L. major in C57BL/6 mice Vinicius Dantas Martins | 1889 - Zileuton Efect In a Murine Model of Acute Respitatory Syndrome (SARS) Induced By A Betacoronavirus Rafaela das Dores Pereira |
| 10:45 - 11:15 | BREAK | ||
| 11:15 - 12:00 | Keynote Conference 2: Claudia Kemper (NHLBI / USA) Complement-controlled amino acid usage paces Th1 responses Chair: Marcelo Bozza (RJ) |
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| 12:00 - 14:00 | BD BIOSCIENCE Symposium Discover the road to high-dimensional biology Robert Balderas 12:30 - 13:30 | LUNCH TIME | |
| Afternoon | Room 1 | Room 2 | Room 3 |
| SYMPOSIUM 4: Mucosal Immunology Chair: Ana Maria Caetano Faria | SYMPOSIUM 5: Innate Immunity Chair: Larissa Dias Cunha (USP / SP) | SYMPOSIUM 6: Host Defense Chair: Claudia Brodsky (FioCruz / RJ) |
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| 14:00 - 14:30 | Host metabolism impact by gut homeostasis disturbances in inflammatory diseases Vinicius Andrade-Oliveira (UFABC / SP) | Metabolic control of inflammatory cell death Charles Lee Evavold (MIT / USA) | TNF-induced reprogramming of host glucose metabolism plays a key role in controlling Plasmodium cell cycle and disease. Ricardo Tostes Gazzinelli (UFMG / MG) |
| 14:30 - 15:00 | Dietary modulation of intestinal immune responses through neuroimmune circuits Jhimmy Talbot (FHCRC / USA) | Metabolite signaling as a regulator of inflammation Evanna Mills (DFCI / USA) | Immune memory in children after SARS-CoV-2 infection Cristina Bonorino (UFCSPA / PA) |
| 15:00 - 15:30 | The role of gut microbiota metabolites on infectious diseases Angelica Thomaz Vieira (UFMG / MG) | Oxidative phosphorylation in the regulation of myeloid cell function David Sancho (CNIC / Spain) | Interferon-gamma, mitochondria and the pathogenesis of Chagas disease cardiomyopathy Edecio Cunha Neto (FMUSP / SP) |
| 15:30 - 15:45 | 2203 - Efferocytosis of Renca-apoptotic cells promotes suppressive effects on dendritic cells supported by glycolysis Ludmilla da Silva Pereira | 2219 - Inflammatory stimuli lead to translational stress in activated macrophages Rodrigo Dias Requião | 1916 - Death among hematologic cancer patients presenting COVID-19 is defined by a broad T cell exhaustion and a cytokine-release syndrome profile Flávio Pignataro-Oshiro |
| 15:45 - 16:00 | 2009 - Metabolic characterization of Foxp3+ RORgt+ T cell population in the experimental model of colitis associated colorectal cancer Marcella Cipelli | 1927 - Maturation, Mobilization And Inflammatory Profile of Neutrophils In Experimental Malaria Lucas Freire-Antunes | 1998 - Arginase 1 is a marker of protection against illness in contacts of leprosy patients Rhana Berto da Silva Prata |
| 16:00 - 16:15 | 2043 - Aryl hydrocarbon receptor is necessary to restrain tissue macrophage inflammatory tonus and systemic glucose homeostasis during obesity Bianca Gazieri Castelucci | 1975 - The Influence Of Erythrophagocytosis On Mouse Melanome Associated Macrophages Luis Batista Tan | 2163 - Lipid droplets contribute to SARS-CoV-2 infection and inflammatory process in human cells Suelen da Silva Gomes Dias |
| 16:15 - 16:50 | BREAK | ||
| 17:00 - 17:50 | Keynote Conference 3: Jeff Rathmell (VUMC / USA) Fueling and Firing up T cells in Inflammation and CancerChair: Alexandra Ivo Medereiros (UNESP / SP) |
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| 18:00 - 19:30 | Assembleia da SBI | ||
| 19:30 - 21:30 | POSTER EXHIBITION | ||
| Room 1 | Room 2 | Room 3 | |
| 8:00-8:50 | BD BIOSCIENCE course Single cell Mutiomics: the potential of RNAseq and protein expression in a single methodology. | ||
| Morning | Room 1 | Room 2 | Room 3 |
| SYMPOSIUM 7: Adaptive Immunity Chair: Gustavo Amarante-Mendes (USP / SP) | SYMPOSIUM 8: Cellular Immunology Chair: Denise Morais da Fonseca | SYMPOSIUM 9: Immunoregulation Chair: André Báfica (SC) |
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| 9:00-9:30 | The curious case of gamma-delta T-cells in Chagas disease cardiomyopathy Walderez Ornelas Dutra (UFMG / MG) | Lipids biosynthesis pathway informs about systemic inflammation in cutaneous leishmaniasis Valéria Borges (IGM - FioCruz / BA) | The complex diet-microbiota-immune cell interactions involved in regulating colonic epithelium responses Marco Vinolo (UNICAMP / SP) |
| 9.30-10:00 | Adjuvant-elicited CD8+ T cell responses: what infections have failed to teach us Ross M. Kedl (CU Anschutz / USA) | Chromatin dynamics and gene expression in host-microbiota interactions in the gut Patrick Varga-Weisz (Essex / UK) | Metabolic changes in osteoclasts are crucial for bone loss in osteolytic diseases Sandra Fukada (USP / SP) |
| 10:00-10:30 | BREAK | ||
| 10.30-10:45 | SBI Threza Kipnis Presentation 1873 - Targeting C5AR1 Signaling Ameliorates Covid-19 Pathology Bruna Manuella Souza Silva |
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| 10:45-11:00 | SBI Threza Kipnis Presentation 2137 - Gut Microbiota From Patients With Mild Covid-19 Cause Alterations In Mice That Resemble Post-Covid Syndrome Viviani Mendes de Almeida |
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| 11:00-11:50 | Keynote Conference 4: Peter Murray (MPIB / Germany) Immunological anti-ferroptosis in disease Chair: Marco Vinolo |
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| 12:00-14:00 | LUNCH TIME | ||
| Room 1 | Room 2 | Room 3 | |
| 12:30-13:50 | BECKMAN COULTER Symposium Detection and Enrichment of miRNA in Extracellular Vesicles John Tigges 12:30-13:15 | Oral Presentations SLB Award 1786 - Leukotrienes In Type 1 Diabetes: Activation Of A Distinct Immunometabolic Phenotype In Macrophages Nayara Pereira 1828 - BCG-Trained Macrophages Elicit A Protective Inflammatory Response Against The Pathogenic Bacteria Brucella abortus Ana Carolina Valente Santos Cruz de Araujo 2165 - The Immonosuppressive Microenvironmebt Profile In Low- And High-Grade Glioma Juliete Nathali Scholl 2174 - Zikv Infection During Pregnancy Dysregulates Kynurenine Pathway Thiago Barros do Nascimento de Morais 2228 - Obesity increases blood-brain barrier permeability and aggravates mouse model of multiple sclerosis Gisele de Castro | PENSABIO Symposium Redefine Immunology with Multiomic Single Cell and Spatial Tools Adriana Suarez |
| Afternoon | Room 1 | Room 2 | Room 3 |
| SYMPOSIUM 10: Tumor Immunology Chair: Gustavo Menezes (MG) | SYMPOSIUM 11: Innate immunity Chair: Karina Bortoluci (SP) | SYMPOSIUM 12: Neuroimmunology Chair: Alessandro Farias (SP) |
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| 14:00-14:30 | The opposite roles of glutaminase 1 and 2 in the tumor immune microenvironment Sandra Dias (LNBIO CNPEM / SP) | New roles for the old HIF-1a in the metabolic control of macrophages Pedro Moraes-Vieira (UNICAMP / SP) | Sleep, Stress, and Beyond... Alexandre Keller (UNIFESP / SP) |
| 14:30-15:00 | Immunomodulation and checkpoint inhibition during infection Fernando Fonseca Guimarães (UQ / Australia) | Itaconate as metabolic regulator of endotoxin tolerance Maxim Artyomov (WUSTL / USA) | The role of brain macrophages regulating CSF flow Antonie Drieu (WUSTL / USA) |
| 15:00-15:30 | STAT3 and low density neutrophils as immunomodulatory mechanisms in cancer Ana Paula Lepique (USP / SP) | Metabolic-epigenetic regulation of macrophage phenotype and function Lev Becker (Uchicago / USA) | Coupling oxygen and glucose metabolism in mitochondria: a fine redox control? Antônio Galina (UFRJ / RJ) |
| 15:30-16:00 | BREAK | ||
| 16:00-16:15 | SBI Threza Kipnis Presentation 2215 - Immunization with a RBD/Nucleocapsid fusion protein promotes neutralizing antibody-independent resistance to infection with wild type and SARS-CoV-2 variants of concern Julia Castro |
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| 16:15-16:30 | SBI Threza Kipnis Presentation 1729 - T-cell intrinsic expression of AIM2 promotes Th17 cells differentiation by regulating RORγt activity Jefferson Antonio Leite |
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| 16:30-16:45 | SBI Threza Kipnis Presentation 2202 - Nucleocapsid-specific CD8+ T cells and antibodies characterize immune memory responses in SARS-CoV-2 infected children Júlia Crispim da Fontoura |
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| 16:50-17:50 | Keynote Conference 5: Edward Chouchani (DFCI / USA) Mechanisms of metabolite regulation over immune cell function Chair: Ricardo T. Gazzinelli |
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| 18:30-20:30 | POSTER EXHIBITION | ||
| 22-03:00h | GET TOGETHER | ||
| Morning | Room 1 | Room 2 | Room 3 |
| SYMPOSIUM 13: Metabolism and Beyond Chair: Fernando Queiroz Cunha (FMRP-USP / SP) | SYMPOSIUM 14: Nutrition and Metabolic syndromes Chair: Momtchilo Russo (SP) | SYMPOSIUM 15: Adaptive Immunity Chair: João Viola (RJ) |
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| 9:00-9:30 | COVID-19-related hyperglycemia as a result of hepatic gluconeogenesis Luiz Osório Leiria (FMRP-USP / SP) | Immunological contributions to food quality control Esther Florsheim (ASU / USA) | Control of regulatory T cell homeostasis and function by adenosine signaling. José Carlos Alves Filho (FMRP-USP / SP) |
| 9.30-10:00 | From COVID to Space: Common Dysregulation with Mitochondrial Impacting Immune Functions During Space Flight and COVID-19. Afshin Beheshti (KBR, NASA ARC / USA) | Sphingosine (or lack thereof) and skin host defense during metabolic syndrome Carlos Henrique Serezani (VUMC / USA) | P2RX7 and CD39 in immune response and metabolism Maria Regina D’Império Lima (USP / SP) |
| 10:00-10:15 | 1949 - The role of immune cells infiltration in NAD+ metabolism disturbances during Mayaro virus infection in mice Matheus Atella de Oliveira | 1906 - Mechanisms Of Resistance To Cart- Cell Immunotherapy: Insights From Mathematical Modelling Daniela Silva Santurio | 2113 - Airway administration of postbiotic protects mice against respiratory syncytial virus infection promoting immune tolerogenic profile Krist Helen Antunes |
| 10.15-10:30 | 2188 - Metabolic-trained immunity potentiates SARS-CoV-2 inflammation to worsen Covid-19 disease. Larissa Menezes dos Reis | 2056 - Chronic Ingestioon of Primex-Z, Compared With Other Common Fat Sources, Drives Worse Liver Injury and Enhanced Susceptibility To Bacterial Infections Maísa Mota Antunes | 1848 - Prognostic Value Of Strem-1 For Disease Severity and Mortality in Covid-19 Patients, Cooperative Actions of Leukocytes and MMP-8 Pedro Vieira da Silva Neto |
| 10:30-10-45 | 2236 - Aryl Hidrocarbon Receptor Immunometabolic Role During A Murine Betacoronavirus Experimental Infection Fernando Roque Ascenção | 2240 - T-bet regulates inflammatory macrophages mediators, metabolism and function Webster Leonardo Guimarães da Costa | 1909 - The Epigenetic Modulator CBX4 In CD8 T Cell Differentiation Guilherme Afonso Melo |
| 11:45-11:15 | BREAK | ||
| 11:15-12:00 | Keynote Conference 6: Miguel Soares (IGC / Portugal) Metabolic adaptation as a defence strategy against infection Chair: Alexandre Salgado Basso |
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| 12:00-14:00 | LUNCH TIME | ||
| Room 1 | Room 2 | Room 3 | |
| 12:30-13:50 | PREMIO PESQUISADOR SBI - BD Oral Presentations 12:00-13:30 CATEGORIA JOVEM TALENTO Guilherme Cesar Martelossi Cebinelli - FMRP/USP Priscila Creppas de Souza e Silva - UFSC Thais Nascimento Kimmemgs - IEP /HSL CATEGORIA PESQUISADOR Daniele Carvalho Bernardo Nascimento - FMRP/USP Kamila Guimarães Pinto - IMPG/ UFRJ Rodrigo Nalio Ramos - FMUSP | PENSABIO Symposium Redefine Immunology with Multiomic Single Cell and Spatial Tools Fernanda Mansur |
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| Afternoon | Room 1 | Room 2 | Room 3 |
| SYMPOSIUM 16: Innate immunity Chair: Renata Meirelles Pereira | SYMPOSIUM 17: Cell Communication Chair: Jean Pierre | SYMPOSIUM 18: Host Defense Chair: João Trindade Marques (MG) |
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| 14:00-14:30 | FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation Caroline Junqueira (FioCruz Minas e Harvard Medical School/ MG) | Do not mess up my house! Hepatic niche for macrophages is essential to immune response to injury Gustavo Menezes (UFMG / MG) | Potential implications of NAD metabolism to the antiviral innate immune response Andrea Poian (UFRJ / RJ) |
| 14:30-15:00 | Integration of Methylation Risk Scores (MRS) to Predict Risk and Severity of Immune-Mediated Disease Kathleen C. Barnes (CU Anschutz / USA) | New Signals Governing Adipocyte-Macrophage Crosstalk in the Context of Metabolic Diseases Marcelo Mori (UNICAMP / SP) | Short chain fatty acids and respiratory viral infections. Ana Paula Duarte de Souza (PUC / RS) |
| 15:00-15:30 | How Cryptococcus neoformans dormant cell modulate macrophages metabolism Anamélia Bocca (UNB / DF) | Single-cell profiling of macrophages in the tumor microenvironment: a pan-cancer analysis Mariana Boroni (INCA / RJ) | The cation channel TMEM176B as a target to control inflammation in COVID-19 and in obesity. Marcelo Hill (Institut Pasteur de Montevideo / Uruguay) |
| 15:30-15:45 | 1945 - Evaluation of plasmacytoid dendritic cell differentiation and migration during COVID-19 infection in an experimental model Jéssica Assis Pereira | 2039 - β2 Adrenergic Signaling Stimulates IL-1β Secretion By Inducing Mapk-Dependent Il1b Transcription Filipe M. de Melo | 2064 - Identification of a CXCR3+ CD8+ T lymphocyte subset associated with diminished risk of paradoxical tuberculosis-related immune reconstitution syndrome in patients with advanced HIV infection Rafael Teixeira Tiburcio dos Santos |
| 15:45 -16:00 | 1962 - Heme Impairs Cellular Respiration and Induces Mitochondrial Fission In Macrophages Elisa Beatriz Prestes | 1871 - Serotonin Regulates Cytokine Production By Peripheral Blood Mononuclear Cells of Patients With Major Depression In Response To TLRs Ligands Marcos Octavio Salvaterra Dutra Cafasso | 1935 - T-Cell Exhaustion Induced During Malaria Compromises the Clinical Course Of Cutaneous Leishmaniasis Uyla Onellas-Garcia |
| 16:00 -16:15 | 2073 - Generation and Optimization of anti-CD19 Car-T Cell for Leukemia Immunotherapy Leonardo Ribeiro Batista Silva | 1882 - TLR-4 Signaling In Hepatocytes, But Not In Immune System, Is the Main Driver for Hepatic Metabolic Alterations During Endotoxemia Hortência Oliveira | 1723 - Myeloid-Derived Suppressor Cells Reduce TH1/TH17 Immunity and Promote a More Severe Pulmonary Paracoccidioidomucosis Nicolas William Preite |
| 16:15-16:50 | BREAK | ||
| 17:00-17:50 | Keynote Conference 7: Max Cooper (Emory University / USA) Lymphocyte Evolution in Vertebrates Chair: Jorge Kalil (USP / SP) |
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| 18:30-20:30 | POSTER EXHIBITION | ||
| Room 1 | Room 2 | Room 3 | |
| SYMPOSIUM 19: Obesity and Diabetes Chair: Niels Olsen Câmara (USP / SP) | SYMPOSIUM 20: Adaptive Immunity Chair: José Carlos Alves Filho (FMRP-USP / SP) | SYMPOSIUM 21: Signaling and Lymphocyte Activation Chair: João Viola (RJ) |
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| 9:00-9:30 | Impact of gut microbiota on pancreas-gut interface in autoimmune type 1 diabetes: a focus on regulatory and pathogenic T cells Daniela Carlos Sartori (FMRP-USP / SP) | Metabolic regulation of NK and NKT cells Cristhiane Favero de Aguiar (TCD / Ireland) | Pseudocowpox virus as a vector to enhance the therapeutic efficacy of antitumor T cell responses Rodrigo Nalio (USP/SP) |
| 9.30-10:00 | Modulation of colonic lamina propria macrophages phenotype in high-fat diet-induced obesity Angela Castoldi (UFPE / PE) | Targeting mitochondrial metabolism to influence T cell differentiation and function Tim Sparwasser (JGU / Germany) | Mobilizing lipids as anti-tumor immunotherapy Yinan Gong (University of Pittsburgh / USA) |
| 10:00-10:30 | BREAK | ||
| 10:30-11:20 | Keynote Conference 8: Patricia Bozza (FioCruz / RJ) Immunometabolic functions of lipid droplets in host response to infections Chair: Sérgio Costa Oliveira (MG) |
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| 11:20-12:00 | AWARDS ANNOUNCEMENT AND CLOSING REMARKS | ||